(such as prednisone) for at least six months and are at high risk for fracture. All information is observation-only. Prolia (denosumab) injection, for subcutaneous use. Version: 13.01. hydrochlorothiazide, alendronate, Fosamax, calcium carbonate, Premarin, Tymlos. supplements It blocks the effects of certain bone cells called osteoclasts in breaking down bone tissue. Its recommended that calcium and vitamin D supplements be taken with Prolia. Heres a short list of some of the mild side effects that Prolia can cause. Below are commonly used dosages, but the dosage you receive will be determined by your doctor. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy. But if they become bothersome, talk with your doctor or pharmacist. What should I know about Prolia vs. Tymlos? We comply with the HONcode standard for trustworthy health information. But its not clear whether this side effect occurred in clinical studies. Brush and floss your teeth regularly while receiving this medication. If you develop hypocalcemia, your doctor will typically have you stop using Prolia. Brush and floss your teeth regularly. Tell your doctor if you become pregnant. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider. Prolia is a medicine that may affect the ability of your body to fight infections. Prolia works by targeting a molecule called RANKL that osteoclasts need to work. So be sure to talk with your doctor about any past or upcoming surgery before starting treatment with the drug. Please know that the sponsors of this site are not responsible for content on the site you are about to enter. People administered concomitant immunosuppressant agents (such as prednisone or cyclosporine) or with impaired immune systems may be at an even higher risk. Calcium supplements may help support bone and teeth health. This is called hypocalcemia. Symptoms of a fracture include new or unusual pain in your hip, groin, or thigh. Usually, but it depends. For information about the difference between sex and gender, see this article. Take good care of your teeth and gums while you receive Prolia. Your healthcare professional might talk to you about taking a calcium or vitamin D supplement, although generally its better to get enough of each from your diet. Nausea can sometimes be a symptom of severe constipation. They can also suggest ways to relieve this side effect. These side effects include: Your risk for these serious side effects may be higher if youre older and have certain dental procedures. Some examples of these treatments include: Talk with your doctor about other drugs you may need to take with Prolia. you For a basic overview of Prolia, including details about its uses, see this article. Your doctor or pharmacist can tell you more about the potential side effects of Prolia and ways to reduce them. Common side effects of Prolia can vary depending on which condition the drug is being used to treat. Your doctor may suggest limiting foods that are high in trans fats, such as fried foods. Prolia and Xgeva both contain the active drug denosumab, but they are not approved to treat all of the same conditions. Its recommended that calcium and vitamin D supplements be taken Use of the term male in this article refers to sex assigned at birth. Do not share this medicine with another person, even if they have the same symptoms you have. The most common side effects of Prolia in men with osteoporosis are back pain, joint pain, and common cold (runny nose or sore throat). (Chlorhexidine helps kill germs in your mouth.). If the side effects seem life threatening or you think youre having a medical emergency, immediately call 911 or your local emergency number. But tingling may be a symptom of side effects such as sciatica and hypocalcemia. Your risk may also be higher if you: Stopping Prolia treatment can also increase your risk for bone fractures. Special care may be needed. Medication Guide. If you need to have any dental work (especially surgery), tell the dentist ahead of time that you are receiving this medicine. Data sources include IBM Watson Micromedex (updated 2 Apr 2023), Cerner Multum (updated 17 Apr 2023), ASHP (updated 10 Apr 2023) and others. They can help you decide whether the possible benefits for your condition outweigh your risks for serious side effects. Also, hair loss may be related to other medications you take or health conditions you have. If youre concerned about tingling while using Prolia, talk with your doctor. Coming to a Cleveland Clinic location?Hillcrest Cancer Center check-in changesCole Eye entrance closingVisitation and COVID-19 information, Notice of Intelligent Business Solutions data eventLearn more. Policy. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. What are some frequently asked questions about Prolia? Before your appointment, write down questions, such as: How will Prolia affect my body, mood, or lifestyle? MNT is the registered trade mark of Healthline Media. You may take the carton out of the refrigerator and allow it to reach room temperature before the injection is given. Talk to your health care professional or pharmacist for more information. Prolia improves bone mass and increases bone mineral density. Prolia contains the active drug denosumab, and Reclast contains the active drug zoledronic acid. Youll receive 60 mg/mL of Prolia once every 6 months. Prolia may lower the calcium levels in your blood. NOTE: This medicine is only for you. Talk with your doctor or health care professional about your birth control options while taking this medicine. If youre using Prolia and feel fatigued despite getting enough sleep, talk with your doctor. As with most drugs, Prolia can cause an allergic reaction in some people. Tell your doctor about all other medicines you use. However, drinking too much alcohol may raise your risk of falling. Sciatica was a less common side effect in females* who received Prolia for osteoporosis after menopause. Symptoms of a mild allergic reaction can include: A more severe allergic reaction is rare but possible. If youre concerned about unexplained weight gain while using Prolia, talk with your doctor. Your doctor should examine your mouth before you start Prolia and may tell you to see your dentist. Continue reading, Yes, Prolia does appear to weaken your immune system. Do not take this medicine with any of the following medications: This medicine may also interact with the following medications: This list may not describe all possible interactions. Learn more about the unique risk factors for osteoporosis in, Osteoporosis weakens bones, which leads to breaks in the hips, wrists, and spine. Its a prescription drug thats used to treat osteoporosis and other forms of bone loss. Increased risk of broken bones, including broken bones in the spine, after stopping, skipping or delaying Prolia. Both medications are approved to treat certain people with osteoporosis, as well as people with other conditions. How long will the side effects of Prolia last? If youd like more information about Prolia use during pregnancy or while breastfeeding, talk with your doctor. If youve had surgery on your thyroid or parathyroid glands, you may have an increased risk of a low level of calcium in your blood. This helps treat osteoporosis by improving bone mass and strengthening your bones. Bone pain from Prolia may be most noticeable in your arms and legs. Tell your doctor if you become pregnant. Your doctor may have you take extra calcium and vitamin D while you are being treated with Prolia. Prolia - Patient Information Leaflet (PIL) - (emc) - medicines If youre breastfeeding, you should not receive Prolia. Use of the terms female and male in this article refers to sex assigned at birth. Youll likely have questions about your condition and treatment choices. Before taking Prolia, tell your doctor about all of your medical conditions, including if you: Your healthcare provider should do a pregnancy test before you start treatment with Prolia. Yoga for Osteoporosis: 5 Beneficial Poses, Diet and Osteoporosis: Nutrients, Diet Tips, and More. Prolia can cause certain side effects, some of which are more common than others. There is a potential for serious side effects to an unborn child. Before you start Prolia treatment, talk with your doctor about how long Prolias side effects may last. Your doctor can check if you have osteoporosis, have low BMD, or have osteopenia by measuring your bone density. What's the difference between Prolia and Reclast? Since different people It is important not to miss your dose. Do not stop, skip or delay taking Prolia without first talking with your doctor. You may also want to do some research on your own. Having a tooth extraction while youre using Prolia may increase your risk for these side effects. in your skin, lower stomach area (abdomen), bladder, or ear may happen. Symptoms of a severe allergic reaction can include swelling under your skin, typically in your eyelids, lips, hands, or feet. Before starting Prolia treatment, talk with your doctor about any tooth procedures you have scheduled. 8,432 people who take Prolia and Calcium together, and have interactions are studied. They may also have you see your dentist. This could include having: Before taking Prolia, share your dental history with your doctor. So your healthcare provider will likely ask you to take calcium and vitamin D supplements if youre not taking them already. To learn how Prolia and Tymlos are alike and different, see this comparison. Do not share this medicine with others. Peripheral edema is a less common side effect that was reported in clinical studies of females* who received Prolia for osteoporosis after menopause. Pain, specifically musculoskeletal pain, is one of the most common side effects of Prolia. This is because the drug may be harmful to a growing fetus. have low blood calcium; or are pregnant or plan to become pregnant, as Prolia may harm your unborn baby; or are allergic to denosumab or any ingredients in Prolia. And some of these side effects are more common with certain uses of Prolia. Continue reading, Prolia is a prescription medicine injected under the skin (called a subcutaneous injection) and is given once every 6 months. Drug class: Miscellaneous bone resorption inhibitors. These supplements help to prevent a low calcium level while youre taking Prolia. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. Serious infections may occur during treatment with Prolia. You can learn more about how we ensure our content is accurate and current by reading our. DENOSUMAB (den oh sue mab) slows bone breakdown. To learn about other mild side effects, talk with your doctor or pharmacist, or read Prolias medication guide. You may wonder how Prolia compares with the alternative drug Reclast. Talk with your doctor if youd like to know about taking generic denosumab. Having dental procedures, including tooth extractions, during Prolia treatment may increase your risk of dental side effects. you can take. They can also happen if you have certain conditions or if you take certain medications. For more information, you can refer to the drugs prescribing information. Prolia also carries a warning about hypocalcemia, which is a low level of calcium in the blood. Also, its important to brush and floss your teeth regularly while youre using Prolia. But certain choices and habits accelerate the process. Prolia is a prescription medicine used to treat osteoporosis in men and women who will be taking corticosteroid medicines Starting an osteoporosis drug? Here Other studies have examined the risk of damage to jaw tissue with the use of bisphosphonates, one type of medication commonly used to treat osteoporosis. Some people who take Prolia develop severe bone, joint, or muscle pain. Prolia can cause many serious side effects. Had parathyroid or thyroid surgery (glands located in your neck), Have been told you have trouble absorbing minerals in your stomach or intestines (malabsorption syndrome), Have kidney problems or are on kidney dialysis, Are taking medicine that can lower your blood calcium levels, Plan to have dental surgery or teeth removed, Are breast-feeding or plan to breast-feed. Your side effects from Prolia may also vary depending on your gender. I am taking Prolia and just saw that it's important to take Calcium because Prolia takes the calcium out of the blood and that can cause problems. eHealthMe is studying from 138,307 Prolia users for its effectiveness, alternative drugs and more. For example, an over-the-counter pain reliever can often ease mild pain such as joint or muscle pain, or headache. Is the ketogenic diet right for autoimmune conditions? Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. And ask your doctor about which drug is right for your condition. To learn more about this side effect, see Side effect specifics below. The risk is highest in people with cancer, blood cell disorders, pre-existing dental problems, or people treated with steroids, chemotherapy, or radiation. Do any of yall know? Over time, Prolia can reduce bone loss and make your bones stronger. If your levels are high, theyll typically recommend lifestyle changes and medication. Use effective birth control while using denosumab and for at least 5 months after your last dose. If you are a healthcare professional, click "I Agree" to continue. If youre able to become pregnant, your doctor will order a pregnancy test for you before you take Prolia. Biosimilars usually cost less than brand-name drugs. Use of the term female in this article refers to sex assigned at birth. These can include tingling or numbness in the hands, feet, and face. They may help you identify other possible causes or suggest ways to help manage hair loss. Prescribing Information and With low BMD your bone tissues have less mineral, which means they become weaker. If you have bothersome or severe side effects or other problems while taking Prolia and need to stop the medication, your doctor will monitor your bone mineral density. In addition, you should use effective birth control while youre taking Prolia. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. You might wonder how Prolia and the drug Xgeva compare. We do not endorse non-Cleveland Clinic products or services. These lists dont include all possible side effects. Store in the original container away from heat and light. You should not breastfeed while using this medicine. Let your doctor know if you have questions about which drug is recommended for you. American Dental Association (ADA) recommendations say that tooth extractions are allowable if needed during Prolia treatment, if both you and your dentist agree. Continue reading, While there are no known drug interactions between Prolia (generic name: denosumab) and alcohol, but you should check with your doctor first before you drink. Prolia Subcutaneous: Uses, Side Effects, Interactions, Pictures Vertigo (dizziness) was reported in some females* using Prolia for osteoporosis. This drug may decrease your body's ability to fight infection. Learn more about the FRAX score and the treatment options for, Medical News Today has strict sourcing guidelines and draws only from peer-reviewed studies, academic research institutions, and medical journals and associations. And you should continue using birth control for at least 5 months after stopping Prolia. How Viagra became a new 'tool' for young men, Ankylosing Spondylitis Pain: Fact or Fiction, https://www.ada.org/en/member-center/oral-health-topics/osteoporosis-medications, https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/125320s210lbl.pdf, New clues to slow aging? Learn more about your health after menopause. Various types of osteoporosis medications are available. According to the American Dental Association, your risk of this problem may increase if you receive denosumab (the active drug in Prolia) for longer than 2 years. Get useful, helpful and relevant health + wellness information, 9500 Euclid Avenue, Cleveland, Ohio 44195 |, Important Updates + Notice of Vendor Data Event, low levels of calcium or Vitamin D in the blood, an unusual reaction to denosumab, other medicines, foods, dyes, or preservatives, medicines that lower your chance of fighting infection, steroid medicines like prednisone or cortisone, allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue, signs and symptoms of infection like fever or chills; cough; sore throat; pain or trouble passing urine, signs of low calcium like fast heartbeat, muscle cramps or muscle pain; pain, tingling, numbness in the hands or feet; seizures. What should I know about Prolia vs. Evenity? If you have questions about treatment options for osteopenia or arthritis, talk with your doctor. Your risk of bone fractures can increase when you stop, skip or delay using Prolia. This list doesnt include all possible mild side effects of the drug. Call your doctor or go to your nearest emergency room right away if you have any symptoms of a serious allergic reaction, including low blood pressure (hypotension); trouble breathing; throat tightness; swelling of your face, lips, or tongue; rash; itching; or hives. To learn more about this, see the How is Prolia administered? section below. This includes proper brushing, flossing, mouthwash use, and regular professional dental cleanings. You might like to know how Prolia and the drug Evenity compare. Hair loss with Prolia is rare, and whether Prolia is responsible for this effect isnt known. Kidney problems. And if you have osteoporosis, falling could increase your risk of fractures. Denosumab Injection: MedlinePlus Drug Information If the user is trying to grow bone due to osteoporosis, osteopenia, or any reason, the recommended intake is 4 capsules divided into 2 doses also taken in the morning and evening with food. Allergic reaction. Use of the terms female and male in this article refers to sex assigned at birth. Your risk for some health conditions increases when you are postmenopausal. Prolia With peripheral edema, fluid builds up in your body and causes swelling in your arms and lower legs. Prolia can cause peripheral edema (fluid retention) or swelling, and this may lead to weight gain in some people. Talk with your doctor before starting Prolia treatment. WebProlia is used to treat osteoporosis in women after menopause and in men, and in people For more information, you can refer to the drugs prescribing information. It can have some side effects, but these may depend on who uses it. Women going through menopause have a higher risk of developing osteoporosis. Talk with your doctor about your health history and discuss your risks with Prolia treatment. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.). If you plan to drink alcohol while using Prolia, ask your doctor how much is safe to drink. low calcium level--muscle spasms or contractions, numbness or tingly feeling (around your mouth, or in your fingers and toes). Your doctor can discuss with you how to manage side effects and whether youll need to stop taking Prolia due to side effects. Vertigo (dizziness) was reported in some people who received Prolia for osteoporosis, but this was a less common side effect. BMD was increased by 8.8% at the lumbar spine, 6.4% at the total hip, and 5.2% at the femoral neck in trials that measured BMD after three years of treatment with Prolia. Different individuals may respond to medication in different ways. (A low blood calcium level is a possible side effect of Prolia.). You can often relieve mild pain in your back or bones with an over-the-counter (OTC) pain medication.