"That's why he's one of the best [defensive] ends/outside 'backers ever." Giants 24, Chargers 23 -- Jordan Raanan, The Cardinals are 0-2 this season against NFC teams not in their division, but the biggest question mark will be whether the Cardinals can keep Carson Palmer on his feet. See Week 5 rankings. NFL Nation reporters predict the outcomes and scores for Sunday's and Monday's Week 5 games. Spread: GB -8.0 (41), What to watch for: This could be a nightmare matchup for the Packers' defense. The Saints quarterback is remarkably 2-0 as Drew Brees' replacement, but he has thrown for an average of only 185 yards per game in those two starts. Betting nugget: Philadelphia is 3-0 ATS against Pittsburgh since 2008. That would help against a Lions offensive line featuring three solid first-round picks in left tackle Taylor Decker (2016), center Frank Ragnow (2018) and right tackle Penei Sewell (2021). He has also been sacked 11 times, tied for the eighth most in the NFL. In that case, at home, Stafford has the edge. No one really knows what to expect. Bengals quarterback Joe Burrow has excelled in his past eight road games, going 6-2 with 18 touchdowns and four interceptions. Betting nugget: All four Bills games have gone under the total this season. They have the NFL's second-ranked rushing defense, surrendering only 59.3 yards per game, and they held Christian McCaffrey to just 37 rushing yards in Week 2 (53 all-purpose yards) and the Rams to just 28 total rushing yards in Week 4. 125 attempts). What to know for fantasy: T.J. Hockenson had 24.2 fantasy points through three weeks before exploding for a career-best 39.9 points last week against the Seahawks. Betting nugget: Both times Rodgers faced the Cowboys in Dallas, Green Bay won the game outright as an underdog (2016 divisional round and 2017 Week 5). But the key in this one will be the ability of the Carolina defense to make the Lions one-dimensional and force Matthew Stafford to beat them. Betting nugget: Atlanta has failed to cover 13 straight games against AFC opponents (1-12 outright). FPI prediction: CHI, 63.5% (by an average of 4.8 points), Matchup must-reads: Mack expected to be with the Raiders 'for the long haul' Daniel embraces seldom-used, uncertain backup QB life Roquan Smith says he's playing Sunday Carr: Burfict's 'heart is broken;' QB says ban isn't fair, 1 p.m. Jalen Ramsey to the Eagles: What are the realistic odds? The Vikings are banged up on offense but probably still good enough to squeak out a close victory. Pickett was picked off three times while playing in the second half last week vs. the Jets, and his ability to make good decisions on the road will go a long way against a defense tied for the league lead in interceptions (seven). What to know for fantasy: When you see "Brady vs. Atlanta," you likely think about the Super Bowl comeback, but that's not going to help you. -- Turron Davenport, Bold prediction: The Bills, who possess the NFL's fourth-best rushing attack in terms of yards per game, will run for at least 150 yards against a Titans defense that has given up a combined 146 rushing yards over its past two games. It all culminates with a Monday Night Football matchup between the Raiders and the Chiefs on ESPN. Spread: KC -7.0 (51), What to watch for: The Raiders might need to score a big number in order to win. Read more. 2023 NFL mock draft: Matt Miller's seven-round predictions, picks - ESPN This could be Rodgers' breakout game. . The Cowboys will be the third pass defense the Rams have faced so far ranked in the top seven, and their varied pass rush will make life difficult for Stafford. -- Mike Triplett, Everything you need this week: Stat to know: The Dolphins' 11-2 record since 2021 Week 9 is tied with the Chiefs for best in the NFL. Inside Kelly Kleine's historic journey, from Vikings to Broncos Justin Fields, Bears' struggling passing game looking for answers Vikings riding ups and downs as Cousins learns new scheme, What to watch for: The Dolphins, aiming to put aside the Tua Tagovailoa concussion controversy, hope to improve to 4-1 for the first time since 2003. See Week 5 rankings. -- Sarah Barshop, Bold prediction: The Falcons, who have been outscored 38-10 in first quarters this season, will actually have the lead after the first frame in Houston. Finally, Seth Walder and Eric Moody give us final score picks for every game. -- Turron Davenport. -- Rob Demovsky, Bold prediction: Aaron Rodgers throws for 300-plus yards and at least three touchdowns. Read more. Things are lined up -- on paper at least -- for the 49ers to get their first victory of the season. Just like in life, it . What to know for fantasy: Dalvin Cook has rushed for a touchdown in all four weeks this season and has seen his reception total increase each week as he continues to make a bid as a top-tier fantasy RB. The Cowboys will want to prove last week was more of a fluke than a trend. But the Commanders' run defense will be severely tested by Tennessee running back Derrick Henry. Steelers 24, Jaguars 10 -- Mike DiRocco, The Steelers' offense is poised to break out eventually; Ben Roethlisberger has only one completion of more than 40 yards this season -- which came in Week 2, his only home game. 3 all-time rusher Barry Sanders, Meet Brady's most trusted teammate: His 1995 shoulder pads, Redskins' January decision to maintain status quo looks bad in hindsight, Patriots' offense searching for identity, as it did in 2018, Big pass plays tearing up Ravens' defense, 'Do whatever' to win: Steelers bring back the Wildcat, Raiders hoping to reverse London trend by changing travel schedule, Left with no defense, Jackson needs to carry Ravens this season, Steelers' first draft by Khan 'aggressive', Mack expected to be with the Raiders 'for the long haul', Daniel embraces seldom-used, uncertain backup QB life, Carr: Burfict's 'heart is broken;' QB says ban isn't fair, Analyzing how, where Golden Tate fits into Giants' offense. What to know for fantasy: Receiver Sammy Watkins scored 46.8 points in Week 1, but that is 18.1 more fantasy points than he has scored in the three weeks since. Elliott is coming off the third-fewest rushing yards of his career, yet the Packers are allowing 142.3 yards per game and 5.0 yards per carry. NFL picks, predictions for Week 5: Cardinals crush 49ers; Steelers stop ET | NFL Network QB Teddy Bridgewater is 2-0 lifetime against the Jets, who look to go over .500 for the first time since a 1-0 start in 2018. Stat to know: The Patriots are looking to become the first team since the 1988 Browns and Dolphins to allow zero passing touchdowns in the first five games of the season. Chargers 20, Giants 19 -- Eric Williams, The Giants are at home in a game they badly need to keep from imploding. Steelers 27, Jaguars 20 -- Jeremy Fowler, The Seahawks are coming off one of the more dominant halves of football they've played under Pete Carroll, outscoring the Colts 36-3 and holding them to 32 yards in the second half last week. Irrelevant' pick on Toledo's Johnson, Chargers go all-in on TCU with Duggan pick in 7th, 10 fantasy football breakout players for 2023, Will Levis opens up about emotional draft day, Steelers' first draft under Omar Khan was 'aggressive' and achieved high marks, After hoopla of going No. McManus's pick: Eagles 30, Jets 17 Listed at 5-foot-8, 187 pounds, he stood tall against Denver last week with a 68-yard scoop-and-score TD and played tough defense against Jerry Jeudy. The role is great, but don't forget DeAndre Hopkins' suspension has just two weeks left on it. More NFL coverage , Bold prediction: The Bucs will hold Alvin Kamara under 100 all-purpose yards and under 45 rushing yards. Betting nugget: Minnesota is 22-10-1 ATS after a loss under Mike Zimmer. He is the first player with nine sacks through the first four games of a season since Kabeer Gbaja-Biamila recorded nine in 2001. Stat to know: Rodgers is averaging 6.2 air yards per attempt, his fewest through four games since becoming a starter in 2008. Betting nugget: Chicago is 4-12 ATS as an underdog since the start of last season. It's ranked fourth in rushing yards allowed per play (3.2), while the Eagles are ranked fifth in rushing yards gained per play (4.7). Walder's pick: 49ers 23, Panthers 14 NFL odds, Vegas lines, picks, spreads, bets, predictions for Week 5 Stat to know: JuJu Smith-Schuster's 15 receiving yards against the Bengals were the fewest he has had in a regular-season game in which he registered at least one reception. The story of the Cowboys scout and prospect son Dallas just drafted, Legacy pick: Cardinals take great-great-nephew of team's first-ever draft pick, Winston already improving under 'QB whisperer' Bruce Arians, Yes, he's 2-0, but the Saints will need more from Bridgewater, Matthew Berry's Love/Hate for Week 5: How to make a trade, NFL experts predict: Week 5 upset picks, fantasy football flops and sleepers, How Watson's 'NFL experience' began as ball boy for the Falcons, TE Hooper could be the next Falcon to cash in, Taylor Lewan's return could be a boon for Titans' offense, Gore closing on No. Raiders 23, Ravens 16 -- Paul Gutierrez, Three key players from the Packers playoff victory over the Cowboys are gone -- Jared Cook (the tight end who caught the sideline pass to set up the game-winning field goal), Micah Hyde (the safety who had an interception) and T.J. Lang (the Pro Bowl guard who protected Aaron Rodgers). -- Tim McManus. Another one of its Week 5 NFL predictions: The Packers (-3) cover on the road against the Bengals in a matchup of 3-1 teams. Chiefs 27, Texans 20 -- Sarah Barshop, The Vikings' defense aims to take advantage of Mitchell Trubiskys inexperience at quarterback by disguising coverages and playing hide-and-seek with its blitzes. Stat to know: Cincinnati's Joe Mixon is averaging a career-low 3.2 yards per rush and 37.3 yards per game this season. Additionally, the Eagles are averaging a league-high 8.79 passing yards per play while the Cardinals are giving up 7.36, which ranks 25th in the league. Betting nugget: Smith is 23-15 ATS in his career, including 10-2 ATS in his past 12 starts and 5-2 ATS with Seattle. Given the Colts' struggles protecting the quarterback (they've allowed 14 sacks, tied for fifth most in the league) and the Niners' ability to take advantage of porous offensive lines (nine sacks total against Seattle and Arizona), this would seem to be the type of game the 49ers can win. Trotter's pick: Browns 20, 49ers 16 The Bills and Steelers matchup, discussed in greater detail below, moved from Buffalo minus-8 to Buffalo minus-14, but a perhaps. All newly updated picks . Read more. NFL expert picks, predictions, lines for Week 5 highlighted by the Giants at Green Bay, Dallas at the Rams, and Las Vegas at Kansas City NFL Expert Picks, Predictions: Week 5 * next to the pick means the team will win, but not cover. CFB: The way-too-early top 25 for 2021 ARI-CIN | DEN-LAC | GB-DAL This is the second-longest current home losing streak in the NFL behind the Cardinals, who have dropped seven in a row at home. Here's how Week 5 is shaping up as we continue through the 2021 season CBSSports.com . Bosa dominated Carolina in 2019 with three sacks and an interception. -- DJ Bien-Aime. The Chiefs' offense is a complete running and passing groove with Patrick Mahomes. Matchup rating: 63.6 | Spread: HOU -5 (49), What to watch for: Will wide receiver DeAndre Hopkins top 100 receiving yards against Atlanta? Young is NFL-ready thanks to his fast . Chalk home | NFL home | CFB home, Bold prediction: The Cardinals' passing game will finally lead them to a win. -- Todd Archer, Bold prediction: The first team to 30 rushing attempts will win. Game of Midweek: Colts at Broncos (-3.5, 44 o/u) . They're tied for fourth with 25 explosive pass plays (16-plus yards), and Miami's banged-up secondary is giving up huge chunks in the passing game (31st in yards). -- Rob Demovsky. Last week, we hit the Falcons at +3. Bold prediction: With quarterback Sam Darnold (mono) sidelined for a third straight game, the Jets' epic struggles on offense will continue. Matchup rating: 9.9 | Spread: CIN -3 (46.5), What to watch for: The game between winless teams could feature multiple sacks. Barshop's pick: Texans 20, Falcons 17 Wentz's seven picks are the most in the NFL. Bengals 13, Bills 9 -- Mike Rodak, The Bengals have a tough matchup against one of the league's best defenses (Buffalo is 10th overall), but it looks like their offense finally has begun to click in the past two weeks. The Bills' offense -- which has gone three-and-out on 48 percent of drives this season, second most in the NFL -- will be playing short-handed at wide receiver because of a thumb injury to No. MIN-NYG | NYJ-PHI | JAX-CAR The Rams took their first loss, and the. Read more. Moody's pick: 49ers 27, Panthers 10 -- Ben Baby. After catching eight passes for 111 yards in the season opener, he has not reached 70 receiving yards in any of the past three games. Wells' pick: Chiefs 41, Colts 24 Cronin's pick: Giants 21, Vikings 17 That includes losses to the Titans and Colts in the past two weeks. Rams 24, Seahawks 23 -- Brady Henderson, The Rams are feeling really good about themselves, coming off a big road win against the Cowboys. NFL Week 5 picks, predictions: Colts vs. Broncos | Giants vs. Packers | Steelers vs. Bills Chargers vs. Browns | Texans vs. Jaguars | Bears vs. Vikings Lions vs. Patriots | Seahawks vs.. The Patriots have allowed a league-high five touchdowns to tight ends this season. No, Williams isn't the greatest running back of all time -- or possibly even the best overall on his team -- but he has proven to be consistent and durable behind a strong offensive line. Atlanta is the only team this season undefeated against the spread. Christian McCaffrey, the eighth pick, leads the NFL in rushing with 411 yards, and Jacksonville's Leonard Fournette, the fourth pick, isn't far behind with 404. Stat to know: Daniel Jones needs two passing touchdowns and 72 passing yards to have the most in each category by a Giants quarterback in his first three NFL starts since the 1970 merger. Walder's pick: Rams 27, Cowboys 17 Unless, of course, two guys who never played with Mack in Oakland -- right tackle Trent Brown, whom the Raiders feted with a four-year, $66 million contract, and left tackle Kolton Miller, the Raiders' first-round pick a year ago -- have something to say about it and keep quarterback Derek Carr clean. ET | ESPN The NFL Week 5 schedule features a bevy of intriguing matchups including the Rams vs. Seahawks on Thursday Night Football in a matchup between two NFC East teams with championship aspirations; the Browns vs. Chargers in a battle between two surprising contenders in the AFC; the 49ers vs. Cardinals in a critical NFC West tilt featuring MVP -- Ben Baby, NFL: Brady a rare Super Bowl underdog passing windows despite a smaller 5-foot-10, 204-pound frame. FPI prediction: MIN, 71.6% (by an average of 7.9 points), Matchup must-reads: Jones brings new energy, hope to Giants What's happened to Thielen and Diggs? ET | FOX Spread: NE -3.0 (45.5). 1, Panthers' Bryce Young is all 'business now', Top picks Christian Gonzalez, Keion White reflect Patriots' ideal identity, Big takeaways from the NFL draft: A historic QB class, the rebuilt AFC South and new GMs thriving, NFL Nation sizes up all 259 draft selections, XFL semifinals: Defenders roll Sea Dragons, set up title showdown with Renegades.