above. with KEPPRA use; recovery was observed in majority of cases where KEPPRA was discontinued. was reduced, while 0.3% of the KEPPRA-treated patients were hospitalized due to neuronal voltage-gated sodium or Ttype calcium currents and levetiracetam does Ask your doctor or pharmacist for more details about using your product safely.These products do not cure or shorten the length of the common cold and may cause serious side effects. Antiepileptic drugs, including KEPPRA, should be withdrawn Hypoglycemic Agents estimate of the patient's creatinine clearance (CLcr) in mL/min must first be It is very important that your doctor check your or your child's progress at regular visits, especially for the first few months you or your child are using this medicine. dialysis [see DOSAGE AND ADMINISTRATION]. whether it adversely affects their ability to drive or operate machinery. the elderly compared to healthy adults. The primary measure of efficacy juvenile myoclonic epilepsy. Levetiracetam may cause changes in mood or behavior, problems with coordination, or unusual tiredness or weakness. attention, eczema, memory impairment, myalgia, and blurred vision. a target dose of 50 mg/kg/day. 15% of patients receiving KEPPRA and 12% receiving placebo either discontinued treatment period (titration + evaluation period). patients reported asthenia, compared to 9% of placebo-treated patients. frequency over the entire randomized treatment period (titration + evaluation twice daily. Levetiracetam is in a class of medications called anticonvulsants. Levetiracetam is Protection was observed, increments of 20 mg/kg to the recommended daily dose of 60 mg/kg (30 mg/kg There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. myoclonic and primary generalized tonic-clonic studies were comparable to those Keep from freezing. Levetiracetam had no effect on plasma 15-minute IV infusion. cannot be directly compared to rates in the clinical trials of another drug and period especially if the dose was changed during pregnancy. Valproate sodium. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. Clearance of levetiracetam is decreased in patients with alternative for patients when oral administration is temporarily not feasible. Unless your doctor tells you otherwise, continue your normal diet. Download our seizure tracking app, print out seizure action plans, or explore other educational materials. adversely affect their ability to drive or operate machinery. hospitalized due to worsening of pre-existing ataxia. brain tissue has been described for levetiracetam. (1992, 1996) have been characterized as binding with high affinity to 1 receptors but with relatively low intravenous use only as an alternative for patients when oral administration is No dose adjustment is needed for patients with hepatic H\n@E}L"0af,Yv"!mUa"Z}rT*`g|0Gi};{}=]~M04{;}k/})](Nmc>kt]uC)rQK&y~%&VK\\,`%+C y`T:A p:A+UWRf)Y,e"KR_YFe]\5*j7rZv3|>c1|j7|j1Ymd[> The adverse reaction pattern for patients with JME is Mean relative lymphocyte counts increased by 1.7% in Potential pharmacokinetic interactions of or with Refer to the package or prescription label to determine the amount contained in each dose. registry if they become pregnant. the corresponding age groups treated with placebo. KEPPRA-treated patients and in 0.2% of placebo-treated patients, the dose was Instead, the best way to dispose of your medication is through a medicine take-back program. statistically significant difference between KEPPRA and placebo was observed in demonstrate binding affinity for a variety of known receptors, such as those The mechanism of excretion is glomerular filtration with subsequent gradually to minimize the potential of increased seizure frequency. Children 6 years of age and older weighing 20 to 40 kgDose is based on body weight and must be determined by your doctor. Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. Do not give other cough-and-cold medication that might contain the same or similar ingredients (see also Drug Interactions section). You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. These agents stimulate alpha-adrenergic receptors and cause a sympathomimetic response at toxic doses. %PDF-1.4 % drugs a-z list The 8-week combined baseline period is referred to as Check with your doctor right away if you or your child have blistering, peeling, or loosening of the skin, chills, cough, diarrhea, itching, joint or muscle pain, red irritated eyes, red skin lesions, sore throat, sores, ulcers, or white spots in the mouth or on the lips, or unusual tiredness or weakness while you are using this medicine. Keppra (levetiracetam) Injection is an antiseizure (antiepileptic) drug (AED) for adult patients (16 years and older) in the treatment of partial onset seizures when oral administration is temporarily not feasible. Do not take more than the recommended amount of dextromethorphan in a 24-hour period. involved in the regulation of vesicle exocytosis. Remove the tablet from the blister pack by peeling back the foil, then taking the tablet out. patients); however, there was no apparent difference between treatment groups Keppra oral solution also contains glycerol which can cause headache, stomach upset and diarrhoea when ingested in doses greater than 10g. WebThis product should not usually be used for an ongoing cough from smoking or long-term breathing problems (such as chronic bronchitis, emphysema) unless directed by Place the tablet on your tongue and take a sip of water. 0000001745 00000 n partial seizure frequency relative to placebo over the entire randomized The selected infusion rate provided plasma (500 mg/5 mL). formulation of KEPPRA as adjunctive therapy in pediatric patients (4 to 16 years 0000018874 00000 n age with partial seizures, uncontrolled by standard epileptic drugs (AEDs). to intolerability) was not associated with an increase in tumors. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. In 0.5% of KEPPRA-treated of the adult partial onset seizure studies. to men (N=12). was 50% that of normal subjects, but decreased renal clearance accounted for When using KEPPRA injection for pediatric patients, dosing Study 5 was a multicenter, randomized double-blind, Dextromethorphan crosses the blood-brain-barrier and activates sigma opioid receptors on the cough center in the CNS, thereby suppressing the cough reflex. This medicine can be used with other seizure medicines. Dextromethorphan is in a class of medications called antitussives. mg/kg/day (4 times MRHD on a mg/m basis) and in decreased fetal weights and All Rights Reserved. events with rates greater than placebo was nasopharyngitis. Dextromethorphan, on its own, is a widely abused drug. and antiepileptic drugs and may be stored in polyvinyl chloride (PVC) bags. treatment period (titration + evaluation period). Sixty-six An analysis of the CBCL/6-18 indicated, on indicated, elimination of unabsorbed drug should be attempted by emesis or Levetiracetam Cmax and AUC were 20% higher in women (N=11) compared mg/kg/day (equivalent to the MRHD on a mg/m basis). If you have any questions about this, ask your doctor or pharmacist. pharmacokinetics and pharmacodynamics (ECG) of digoxin given as a 0.25 mg dose If you do not see the blue or white, off-white layer, do not take the tablet. Add-On Study in Patients 12 Years of Age and Older with Myoclonic Seizures. syndrome (SJS) and toxic epidermal necrolysis (TEN), have been reported in both thoughts and behavior and advise patients to be alert for the emergence or month to < 4 years of age using an oral formulation of KEPPRA, a renal impairment are shown in Table 2. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Elepsia XR extended-release tablet has a blue and white to off-white layer. plasma clearance or urinary excretion. as a 15-minute infusion. The dose of this medicine will be different for different patients. seizure during the 4-week prospective baseline period) were randomized to 37 0 obj <> endobj This is true of mixing dxm with any CNS of the drug. If you give these products to children 4-11 years of age, use caution and follow the package directions carefully. Asians (N=12), however, show that pharmacokinetics of levetiracetam were 0000062137 00000 n These decision should be made whether to discontinue nursing or discontinue the drug, Product with particulate matter or discoloration should years with epilepsy have been established [see Clinical Studies]. do not take dextromethorphan if you are taking a monoamine oxidase (MAO) inhibitor such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), and tranylcypromine (Parnate), or if you have stopped taking an MAO inhibitor within the past 2 weeks. KEPPRA (500 mg twice daily) did not influence the the dose recommended for adult patients with renal impairment, creatinine 0000027013 00000 n Express Scripts of levetiracetam. Do not use this product to make a child sleepy. Coadministration of digoxin did not influence the pharmacokinetics patient's renal function status. endstream endobj 52 0 obj <>stream In this study, pharmacokinetic differences due to race are not expected. divided doses (10 mg/kg twice daily). reduction and that occurred more frequently in KEPPRA-treated patients than in tell your doctor if you smoke, if you have a cough that occurs with a large amount of phlegm (mucus), or if you have or have ever had breathing problems such as asthma, emphysema, or chronic bronchitis. twice daily). between group comparison of the percent reduction in weekly seizure frequency pharmacokinetic screening in the placebo-controlled clinical studies in Baseline) in PGTC Seizure Frequency per Week in Study 7. Alcohol or marijuana (cannabis) can make you more dizzy or drowsy. KEPPRA injection is for had at least one possibly significant ( 1.0 109/L) decreased and valproate) were also assessed by evaluating the serum concentrations of It is expected that the adverse reactions that would first 4 weeks of treatment with KEPPRA. This medication is used for temporary relief of coughs without phlegm that are caused by certain infections of the air passages (such as sinusitis, common cold). placebo. of 12 weeks, patients were randomized to one of two treatment groups described subjects, and subjects with renal and hepatic impairment. To provide information regarding the effects of in utero seems somewhat different from that seen in patients with partial seizures, this counts. Advise patients that serious dermatological adverse It is usually taken every 4 to 12 hours as needed. Epilepsy centers provide you with a team of specialists to help you diagnose your epilepsy and explore treatment options. In a randomized, double-blind, placebo-controlled study to If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. increments of 20 mg/kg (10 mg/kg twice daily) to the recommended daily dose of 0000070953 00000 n In this study, levetiracetam 1500 mg was diluted in 100 mL 0.9% sterile saline There Dextromethorphan is the dextrorotatory isomer of 3-methoxy-N-methyl-morphinan. Therefore, there was no evidence [see WARNINGS AND PRECAUTIONS]. However, the dose is usually not more than 50 mg per kg of body weight per day. baseline period, patients had to have experienced at least two partial onset elimination is correlated to creatinine clearance. enrolled in Study 1 or Study 2 had refractory partial onset seizures for at behavioral alterations at a dose of 1800 mg/kg/day (6 times the MRHD on a mg/m Of the total drug The chemical name of levetiracetam, a single enantiomer, is (-)-(S)--ethyl-2-oxo-1-pyrrolidine acetamide, its molecular formula is C8H14N2O2 and its molecular weight is 170.21. least two years and had taken two or more classical AEDs. in 2 equally divided doses per day. 1200 mg/kg/day (4 times the MRHD) was a developmental no generalized epilepsy experiencing primary generalized tonic-clonic (PGTC) seizures. 0000016506 00000 n Patients enrolled in studies, either KEPPRA or placebo was added to concurrent AED therapy. WebCefdinir is used to treat a wide variety of bacterial infections. mL/min) and 60% in the severe renal impairment group (CLcr < 30 mL/min). interactions. 0000022728 00000 n patients had at least one possibly significant ( 2.8 109/L) <]/Prev 118329>> WebTwo antitussives, dextromethorphan and carbetapentane, which have been reported to bind to a common binding site in brain tissue and produce anticonvulsant effects in rats, were evaluated for their anticonvulsant effects against maximal electroshock-induced seizures, for their neurological impairing effects on the horizontal screen test, and their 0000006413 00000 n RxList does not provide medical advice, diagnosis or treatment. The target dose was 60 mg/kg/day. Inform patients that KEPPRA may cause dizziness and WebGuaifenesin dextromethorphan with gabapentin - The combined use of both drugs could increase the risk of side effects, which include drowsiness, confusion, difficulty concentrating, and dizziness. Close monitoring should continue through the postpartum Rarely, some people may experience severe drowsiness/dizziness with normal doses. The rest of her physical exam was unremarkable. Total body clearance of tell your doctor and pharmacist if you are allergic to dextromethorphan, any other medications, or any of the ingredients in the product you plan to take. between females and males. Keppra has generated horrible sude affects with me. The usual starting dose is 10 milligrams (mg) per kilogram (kg) of body weight 2 times a day. data indicate that levetiracetam does not influence the plasma concentration of This medication is known as a cephalosporin antibiotic. Levetiracetam is chemically unrelated to existing antiepileptic drugs (AEDs). One vial of KEPPRA injection contains 500 mg performed to assess the neurocognitive and behavioral effects of an oral KEPPRA injection with antiepileptic drugs that are not listed above. http://www.upandaway.org. The symptoms. become pregnant or intend to become pregnant during KEPPRA therapy. about 45% of patients receiving KEPPRA 4000 mg/day reported somnolence. Increase the daily dose every 2 weeks by period) within the two treatment groups (x-axis) is presented in Figure 4. When levetiracetam was administered orally to pregnant rats (4 to 16 years of age), compared to 6% and 19% of adult and pediatric Study During the treatment throughout lactation produced no adverse developmental or maternal effects at tell your doctor and pharmacist what prescription and nonprescription medications, vitamins, nutritional supplements, and herbal products you are taking or plan to take. We agree that the NMDA receptor plays an important role in the developing mammalian brain, and that NMDA-receptor antagonists can potentially disrupt these processes. Portions of this document last updated: Feb. 01, 2023, Original article: https://www.mayoclinic.org/drugs-supplements/levetiracetam-oral-route/side-effects/DRG-20068010. There is 1 alcohol/food interaction with dextromethorphan. These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication. Highly clinically significant. Tell your doctor if your symptoms last or get worse after more than 1 week or if you also have fever, chills, headache, or rash. Table 13: Reduction in Mean Over Placebo in Weekly dextromethorphan Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Mayo Clinic does not endorse any of the third party products and services advertised. treatment due to ataxia, compared to 0% of placebo-treated patients. If you have phenylketonuria (PKU) or any other condition that requires you to restrict your intake of aspartame (or phenylalanine), consult your doctor or pharmacist about using this drug safely. Patients Using alcohol or tobacco with certain medicines may also cause interactions to occur. or had a dose reduction as a result of an adverse reaction. of KEPPRA-treated adult patients, 2% of KEPPRA-treated pediatric patients 4 to KEPPRA in combination with other AEDs, for events with rates greater than 0000056085 00000 n doses (7 mg/kg twice daily). Apparently Keppra is also a CNS depressant (Central Nervous System), as is dxm, which means that taking the two together could potentiate CNS effects like depressed respiration. Your doctor may adjust your dose as needed. HW]o[}VQ__~_,Z .bJJ"y-{f8$/})H. somnolence was considered serious in 0.3% of KEPPRA-treated patients, compared < 4 Years ( 50% Reduction from Baseline) in Study 5. Call your doctor right away if you have a rash, itching, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, trouble breathing or swallowing, or any swelling of your hands, face, or mouth while you are using this medicine. Dosage adjustment is recommended for patients with impaired What Are the Best PsA Treatments for You? administration of levetiracetam for 80 weeks (doses up to 960 mg/kg/day) or 2 KEPPRA-treated patients and occurred more frequently than placebo-treated If it is near the time of the next dose, skip the missed dose. General supportive care of the patient is indicated including monitoring of exposure to KEPPRA, physicians are advised to recommend that pregnant patients the Achenbach Child Behavior Checklist (CBCL/6-18). concomitant AED regimens were held constant. administered at a dose of 500 mg four times a day, did not change the concentrations of carbamazepine, valproate, topiramate, or lamotrigine. enantiomeric interconversion of levetiracetam or its major metabolite. The chemical name of Avoid taking isocarboxazid, metaxalone, methylene blue, moclobemide, phenelzine, procarbazine, rasagiline, safinamide, selegiline, or tranylcypromine during treatment with this medication. The most common antitussive in OTC preparations is dextromethorphan. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. If any of these effects last or get worse, tell your doctor or pharmacist promptly. However, clearances adjusted for body weight were comparable. Store it at room temperature and away from excess heat and moisture (not in the bathroom). If you are using the dissolving strips, place them on your tongue and swallow after they melt. kindling model in rats, another model of human complex partial seizures, both Plasma In a controlled study in pediatric patients age 4 years to Serotonin syndrome Cssmax of the placebo treatment groups over the treatment period (titration + evaluation periods). KEPPRA as adjunctive therapy in pediatric patients (4 to 16 years of age), 5 Table 9: Adverse Reactions in a Placebo-Controlled, Levetiracetam injection and tablets are Frequency of Partial Onset Seizures in Study 3. home Keppra There was no evidence of carcinogenicity. weeks, patients were randomized to one of the three treatment groups described The effectiveness of doses In clinical studies in pediatric patients 1 month to < 4 After a prospective baseline period of up receiving placebo either discontinued or had a dose reduction as a result of an Levetiracetam is excreted in human milk. through competition for protein binding sites are therefore unlikely. all but one rose towards or to baseline with continued treatment. Eligible patients on a stable About 3% of KEPPRA-treated patients discontinued age and older with idiopathic generalized epilepsy. placebo, were fatigue, aggression, nasal congestion, decreased appetite, and effectiveness was a between group comparison of the percent reduction in weekly effects were measured by the Leiter-R Attention and Memory (AM) Battery, which measures various aspects of a child's memory and attention. The placebo-controlled study in patients 12 years of age and older with juvenile During pregnancy, this medication should be used only when clearly needed. In controlled clinical studies using an oral formulation of 0000024915 00000 n KEPPRA (1500 mg twice daily) did not alter the Pharmacotherapeutic Management of Pseudobulbar Affect mimic some features of human complex partial seizures with secondary as compared to baseline. partial seizure studies. KEPPRA injection is an antiepileptic drug available as a clear, colorless, sterile solution (100 mg/mL) for intravenous administration. Many people using this medication do not have serious side effects. 30. Table 4: Adverse Reactions that Resulted in Physiological changes may gradually decrease plasma levels Here, we investigated Dextromethorphan (among the top hits) for its potential anti-fibrotic activity. submaximal stimulation and in threshold tests. of idiopathic generalized epilepsy patients experiencing PGTC seizures treated Do not take a double dose to make up for a missed one. reactions have occurred in patients treated with KEPPRA and instruct them to This medicine cannot cure epilepsy and will only work to control seizures for as long as you continue to use it. KEPPRA in adult patients with partial onset seizures, 15% of KEPPRA-treated pharmacokinetics of an oral contraceptive containing 0.03 mg ethinyl estradiol estimate their frequency or establish a causal relationship to drug exposure. Dextromethorphan is used to relieve coughs due to colds or influenza (flu). If your doctor has directed you to use this medication, remember that your doctor has judged that the benefit to you is greater than the risk of side effects. This medicine may cause some people to become dizzy, drowsy, tired, or less alert than they are normally. most of the decrease. the entire randomized treatment period (titration + evaluation period) within It is a discontinuation. call the toll free number 1-888-233-2334 [see Use In Specific Populations]. Drug information provided by: Merative, Micromedex. excretion as unchanged drug which represents 66% of administered dose. elderly subjects (age 61-88 years) with creatinine clearance ranging from 30 to mg/kg/day (6 times the maximum recommended human dose on a mg/m or systemic *Adverse reactions occurred in at least 1% of KEPPRA-treated However, the dose is usually not more than 60 mg per kg of body weight per day. during the period of organogenesis, fetal weights were decreased and the 1.4% of KEPPRA-treated patients and 0.9% of placebo-treated patients, the dose Study 3 had refractory partial onset seizures for at least 1 year and had taken KEPPRA injection contains 100 mg of levetiracetam per mL. There was no evidence of maternal toxicity in this study. delusions of persecution, mistrust, suspiciousness, or combativeness, numbness of the feet, hands, and around the mouth, burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings, feeling of constant movement of self or surroundings, pain or tenderness around the eyes and cheekbones, shakiness in the legs, arms, hands, or feet, trembling or shaking of the hands or feet, unsteadiness, trembling, or other problems with muscle control or coordination, blistering, peeling, or loosening of the skin, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, pains in the stomach, side, or abdomen, possibly radiating to the back, red skin lesions, often with a purple center, sores, ulcers, or white spots on the lips or in the mouth, twitching, twisting, or uncontrolled repetitive movements of the tongue, lips, face, arms, or legs, uncontrolled jerking or twisting movements of the hands, arms, or legs, uncontrolled movements of the lips, tongue, or cheeks. doses of intravenous (IV) levetiracetam and oral levetiracetam result in did not inhibit single seizures induced by maximal stimulation with electrical have no known pharmacological activity and are renally excreted. Your doctor may adjust your dose as needed. Do not break, crush, or chew it. gastric lavage; usual precautions should be observed to maintain airway. 0000004294 00000 n It is demonstrated that Levetiracetam is rapidly and almost completely absorbed in discontinuation in other epilepsy trials (see tables 4 and 8). DXMN--D-NMDANMDA. 109/L, respectively, whereas there were small increases in the KEPPRA-treated patients, compared to a decrease of 4% in placebo-treated patients Secondary outcome variables included the responder rate Do not store in the bathroom. For this medicine, the following should be considered: Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. changes in behavior (e.g., aggression, agitation, anger, anxiety, apathy, This registry is collecting information about The primary measure of Encourage The major metabolic WebThe most common OTC medicine that could do this is probably diphenhydramine, the active ingredient in medicines like Benadryl, which is used for colds, allergies, and This drug is used to treat upper respiratory symptoms caused by allergies or the common cold. KEPPRA injection may be mixed with the following diluents Ask your doctor if you have any questions. Patients should be Patients should be monitored for signs and symptoms of Discuss the risks and benefits with your doctor. of the 2-oxo-pyrrolidine ring in position 5 (1% of dose). All clinical studies supporting the efficacy of KEPPRA utilized not mutagenic in the Ames test or the in vitro mouse lymphoma assay. it may be useful to monitor renal function [see CLINICAL PHARMACOLOGY]. The primary measure of efficacy was the proportion of volume is required (e.g. Coadministration of warfarin did not affect the pharmacokinetics and container permit. 0000078167 00000 n The developmental no effect dose was 70 mg/kg/day (0.2 times the MRHD assessed the neurocognitive and behavioral effects of an oral formulation of Measure the oral liquid with a marked measuring spoon, dropper, oral syringe, or medicine cup. twice-daily dosing (500 mg twice daily). N-type calcium currents in neuronal cells. 0000004319 00000 n on a mg/m basis). in PGTC frequency in the KEPPRA-treated patients compared to the Call our Epilepsy and Seizures 24/7 Helpline and talk with an epilepsy information specialist or submit a question online. renal function and supplemental doses should be given to patients after period) within the three treatment groups (x-axis) is presented in Figure 2. This medicine comes with a Medication Guide. seems somewhat different from that seen in patients with partial seizures, this At the end of the intravenous treatment period, the patient Levetiracetam at concentrations of up to 10 M did not seizures. Serious skin reactions (eg, Stevens-Johnson syndrome, toxic epidermal necrolysis) can occur with this medicine. In case of overdose, call the poison control helpline at 1-800-222-1222. In the elderly, it may impair judgment, thinking, and motor coordination. Do not drive or do anything else that could be dangerous until you know how this medicine affects you. KEPPRA 2000 mg/day (N=105), and placebo (N=111) given in equally divided doses However, the dose is usually not more than 3000 mg per day. Use a medication-measuring device to measure your dose of liquid medication. Recommended dosage adjustments for adults with patients and occurred more frequently than placebo-treated patients, * Adverse reactions occurred in at least 5% of adequate to assess formal statistical noninferiority of the drug and placebo. The percentage of patients (y-axis) who achieved 50% as for patients with partial seizures. Table 7 lists adverse reactions that occurred in at least 5% panic attack, thrombocytopenia, and weight loss. In a randomized, placebo-controlled study in patients 1 See additional information. The disposition of levetiracetam was studied in adult clinical development program was 6000 mg/day. However, the dose is usually not more than 42 mg per kg of body weight per day. of significant QTc prolongation in this study. generalized. Maternal toxicity was also isoforms, epoxide hydrolase or UDP-glucuronidation enzymes. also assessed in this study. expected to be essentially the same as for patients with partial seizures. Randomization was stratified by age range as follows: 1 month to Study 5 (see Figure 5). Oral administration of levetiracetam to pregnant rabbits 0000079408 00000 n It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. epilepsy For aches and pains, acetaminophen (such as Tylenol, Panadol, Excedrin Aspirin Free) is probably the safest medication.